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Lormetazepam, sold under the brand name Noctamid among others, is a drug which is a short to intermediate acting 3-hydroxy, benzodiazepine derivative and temazepam analogue. It possesses hypnotic, anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. Lormetazepam is not approve for sale in the United States or Canada. license in the UK as 0.5 and 1 mg tablets for short-term treatment of moderately severe insomnia. It is authorize in the Netherlands as 1 and 2 mg tablets, under the brand names Loramet and Noctamid and as generic, available from several manufacturers. It is sell in Poland as Noctofer. A Dutch analysis stated that lormetazepam could be suitable to be included in drug prescribing formularies, although zolpidem, zopiclone, and temazepam appear better.
Lormetazepam is considered a hypnotic benzodiazepine and officially is an indication for moderate to severe insomnia. Lormetazepam is a short-acting benzodiazepine and is sometimes uses for patients who have difficulty in maintaining sleep or falling asleep. Hypnotics should only be in use on a short-term basis or, in those with chronic insomnia, on an occasional basis. Some studies however suggest such treatments retain their effectiveness in the long term – such a lack of consistency in the findings of many studies could be due to the variation of responses to benzodiazepine treatment.
Tolerance, dependence, and withdrawal
The is low risks of tolerance, dependence, and withdrawal when this drug is in use for 2–4 weeks only. Therefore, lormetazepam is generally a safe and effective drug when using for no longer than 2–4 weeks. Some sleep disturbance in the form of rebound insomnia can, however, occur even after short-term usage of 7 days. Those with a history of addiction may be at increased risk of problems of tolerance and dependence especially those with a past history of dependency on sedative hypnotic drugs. Lormetazepam as with other benzodiazepines is generally only recommend for short-term use, due to tolerance and loss of efficacy. Tolerance to and loss of the sedative effects of benzodiazepine hypnotics can occur within 14 days of regular use.